header image
Sarah Durston Ph.D. PDF Print

Sarah Durston is associate professor at the Department of Child and Adolescent Psychiatry and the head of the Neuroimaging Lab (NICHE) in this department. She is affiliated faculty at the Sackler Institute for Developmental Psychobiology in New York. Sarah was recently appointed as a member of the Young Academy of the Royal Netherlands Academy of Arts and Sciences.


Address

Visiting Address: Heidelberglaan 100, 3584 CS Utrecht
Building: UMC Utrecht 
Room number: A 01.447
Postal Address: Neuroimaging Lab, HP A 01.468, Postbus 85500, 3508 GA Utrecht
E-mail : 
 
Phone : +31 30 250 8161   
Fax : +31 30 250 5444

Image

 Research Interests 

The focus of Sarah's research is on investigating typical and atypical brain development, using neuroimaging approaches. She is currently working on several disorders, including ADHD and autism. She is particularly interested in the pathway from genetic susceptibility for neuropsychiatric disorders to associated behavioural deficits. Her research focuses on two aspects of this pathway: 1) the relationship between genetic susceptibility and neurobiological measures and 2) the relationship between neurobiological measures and cognitive deficits.

Links

The NICHE-lab home page in Dutch with lots of information for research participants: http://www.niche-lab.nl

Sackler Institute for Developmental Psychobiology: http://www.sacklerinstitute.org/

Dutch television episode on Sarah Durston’s PhD project: Jota! http:www.teleac.nl/jota/aflevering.jsp?aflnr=38888


The Young Academy of the Royal Netherlands Academy of Arts and Sciences http://www.knaw.nl/dja/


 Publications


Durston S, de Zeeuw P, Staal W: Imaging genetics in ADHD: A focus on cognitive control. Neurosci Biobehav Rev, in press.

 

Durston S: Converging methods in the study of ADHD: What can we learn from genetics and neuroimaging? Development and Psychopathology, in press

Lahuis B, Durston S, Nederveen H, Zeegers M, Palmen SJMC, Schnack H, van Engeland H: MRI-based morphometry in children with Multiple Complex Developmental Disorder (MCDD), a phenotypically defined subtype of Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS). Psychological Medicine, in press

Durston S, Fossella JA, Mulder MJ, Casey BJ, Ziermans TB, Vessaz MN, van Engeland H: Dopamine-transporter genotype conveys familial risk for Attention-Deficit/Hyperactivity Disorder through striatal activation. J Am Acad Child Adolesc Psychiatry 2008;47(1):61-67

Mulder MJ, Baeyens D, Davidson MC, Casey BJ, van der Ban E, van Engeland H, Durston S: Effects of familial risk for ADHD on neural correlates of expectancy and expectancy violations. J Am Acad Child Adolesc Psychiatry 2008;47(1):68-75

Durston S & Konrad K: Integrating genetic, psychopharmacological and neuroimaging studies: A converging methods approach to understanding the neurobiology of ADHD. Developmental Review 2007:27;374–395

Aron AR, Durston S, Eagle DM, Logan GD, Stinear CM, Stuphorn V: Converging evidence for a fronto-basal-ganglia network for inhibitory control of action and cognition. J Neurosci 2007;27(44):11860-11864

Durston S, Davidson MC, Mulder MJ, Spicer JA, Galvan A, Tottenham N, Scheres A, Castellanos FX, Casey BJ: Neural and behavioral correlates of expectancy violations in Attention-Deficit Hyperactivity Disorder. Journal of Child Psychology and Psychiatry 2007;48(9):881-889

Langen M, Durston S, Staal WG, Palmen SJMC, van Engeland H: Caudate nucleus is enlarged in high-functioning, medication-naïve subjects with autism. Biol Psychiatry 2007;62(3):262-266

Casey BJ, Nigg J, Durston S: Behavioral, imaging and genetic Studies suggest new directions in treatment of Attention Deficit Hyperactivity Disorder. Current Opinion in Neurology, 2007;20(2):119-124

Durston S: Op zoek naar de biologische basis van ADHD:Aanwijzingen vanuit cognitie, neuroimaging, psychopharmacologie en genetica onderzoek [Dutch]. Neuropraxis 2007;11:13-16

Zeegers M, van der Grond J, Durston S, Nievelstein RJ, Witkamp Th, van Daalen E, Buitelaar J, van Engeland H: Radiological findings in autistic and developmentally delayed children.  Brain & Development, 2006;28(8):495-499

Durston S, Mulder M, Casey BJ, Ziermans T, van Engeland H: Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for Attention Deficit Hyperactivity Disorder. Biol Psychiatry 2006;60(10):1062-1070

Durston S & Casey BJ: What have we learned about cognitive development from neuroimaging? Neuropsychologia 2006;44(11):2149-2157

Casey BJ & Durston S: From behavior to cognition to the brain and back: What have we learned from functional imaging studies of ADHD? Am J Psychiatry 2006;163(6):957-960

Palmen SJMC, Durston S, Nederveen H, van Engeland H: No evidence for preferential involvement of medial temporal lobe structures in high-functioning autism. Psychol Med 2006;36(6):827-834

Durston S, Casey BJ: A shift from diffuse to focal cortical activity with development: The authors’ reply. Dev Science 2006;9(1):18-20

Durston S, Davidson MC, Tottenham NT, Galvan A, Spicer J, Fossella JA, Casey BJ: A shift from diffuse to focal cortical activity with development. Dev Science 2006;9(1):1-8

Durston S: Integrating neurodevelopmental imaging and genetic designs. Psychiatry 2005;4(12):35-37

Durston S, Fossella JA, Casey BJ, Hulshoff Pol HE, Galvan, A, Schnack HG, Steenhuis MP, Minderaa RB, Buitelaar JK, Kahn RS, Van Engeland H: Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with Attention Deficit Hyperactivity Disorder, their unaffected siblings and controls. Molecular Psychiatry 2005;10(7):678-685

Casey BJ, Tottenham NT, Liston C, Durston S: Imaging the Developing Brain: What have we Learned? Trends Cogn Sci 2005;9(3):104-110

Palmen SJMC, Hulshoff Pol HE, Kemner C, Schnack HG, Durston S, Lahuis BE, Kahn RS, van Engeland H: Increased gray matter volume in medication naive high-functioning children with autism spectrum disorder. Psychol Med 2005;35(4):561-570

Thomas KM, Hunt R, Vizueta N, Sommer T, Durston S, Yang Y, Worden MS: Evidence of developmental differences in implicit sequence learning: An fMRI study in children and adults.  J Cogn Neuroscience 2004;16(8):1339-1351

Durston S, Hulshoff Pol HE, Schnack HG, Buitelaar JK, Steenhuis MP, Minderaa RB, Kahn RS, Van Engeland H: Magnetic Resonance Imaging of boys with Attention Deficit Hyperactivity Disorder and their unaffected siblings. J Am Acad Child Adolesc Psychiatry 2004;43(3):332-340

Durston S, Davidson MC, Thomas KM, Worden MS, Tottenham NT, Martinez A, Watts R, Ulug AM, Casey BJ: Parametric manipulation of conflict and response competition using rapid mixed-trial event-related functional MRI. NeuroImage 2003;20(4):2135-2141

Durston S: A Review of the Biological Bases of ADHD: What have we learned from imaging studies? Ment Retard Dev Disabil Res Rev 2003;9(3):184-195

Durston S, Tottenham NT, Thomas KM, Davidson MC, Eigsti IM, Yang Y, Ulug AM, Casey BJ: Differential patterns of striatal activation in young children with and without ADHD. Biol Psychiatry 2003;53:871-878

Durston S, Thomas KM, Yang Y, Ulug AM, Zimmerman RD, Casey BJ: The development of neural systems involved in overriding behavioral responses. An event-related fMRI study. Developmental Science 2002;5(4):F9-F16

Durston S, Thomas KM, Worden MS, Yang Y, Casey BJ: The effect of preceding context on inhibition: An event-related fMRI study. Neuroimage 2002;16(2):449-453

Durston S, Hulshoff Pol HE, Casey BJ, Giedd JN, Buitelaar JK, van Engeland H: Anatomical MRI of the developing human brain: What have we learned? J Am Acad Child Adolesc Psychiatry 2001;40(9):1012-1020

Casey BJ, Durston S, Fossella JA: Evidence for a mechanistic model of cognitive control. Clin Neurosci Res 2001;1(4):267-282

Cahn W, Hulshoff Pol HE, Bongers M, Schnack HG, Mandl RC, Van Haren NE, Durston S, Koning H, Van der Linden JA, Kahn RS: Brain morphology in antipsychotic-naive schizophrenia: a study of multiple brain structures. Br J Psychiatry Suppl 2002 Sep;43:s66-72

Baaré WFC, Van Oel CJ, Hulshoff Pol HE, Schnack HG, Durston S, Sitskoorn MM, Kahn RS. Volumes of brain structures in twins discordant for schizophrenia. Arch Gen Psychiatry 2001;58:33-40

Book Chapters

Durston S: Neuroimaging in Child Psychiatry. In: Banachewski T & Rohde LA (ed): Advances in Biological Child Psychiatry. Karger press, in press

Casey BJ & Durston S: Cognitive neuroscience approaches to normal and abnormal development. In: Charney DS & Nestler EJ (ed): Neurobiology of Mental Illness, third edition, Oxford University Press, in press

Casey BJ, Durston S, Tottenham N, Eigsti IM, Galvin A, Davidson MC, Fossella JA: Disruption of Frontostriatal Circuitry, Dopamine, and Cognitive Control in ADHD. To be published in D. Barch (Ed.) Cognitive and affective Neuroscience of Psychopathology, Oxford Press, in press

Durston S, Fossella JA, Casey BJ: Neuroimaging as an approach to the Neurobiology of ADHD. In R. Oades (Ed.): Attention-Deficit/Hyperactivity Disorder (AD/HD) and the Hyperkinetic Syndrome (HKS): Current Ideas and Ways Forward, Nova Science Publishers, New York, 2006, pp. 173-184

Durston S, Palmen S, van Engeland H: Neuroimaging as an approach to studying child psychiatric disorders (Dutch). A.H. Schene et al., (Ed.) Jaarboek voor psychiatrie en psychotherapie, 9th edition, Bohn Stafleu van Loghum, Houten, the Netherlands, 2005, pp. 22-29

 


 Research Projects 

Profiling ADHD

DTI in autism

Longitudinal sMRI in autism

MRI correlates of predicting psychosis

fMRI of cognitive control in autism